i smoke quite a bit and have for years. i`ve noticed a difference in my head too (yes, the word fried does spring to mind) but having abused/enjoyed too many e`s, acid and numerous other gunk its hard to tell what did what to my brain. if you believe all these studies you see, eating food(in general) is going to kill us too(story from last week in the news). ps. having not taken much of anything other than pot and alcohol for the last 1-2 years IMHO e`s kill your brain much more than anything else. * written with a spliff in mouth